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KMID : 0363320150360040447
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Journal of Korean Oriental Internal Medicine
2015 Volume.36 No. 4 p.447 ~ p.457
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Effects of Cortex Phellodendri on the Metabolic Function in Experimental Mouse Model of Obesity
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Ma Young-Hoon
Kim Hyo-Jae
Han Yang-Hee
Kim Han-Ok
Oh Jae-Seon
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Abstract
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Objectives: This study was undertaken to investigate how Cortex Phellodendri affects metabolic functional change in an experimental rat model of obesity.
Methods: An obesity model was induced in a C57BL/6 mouse with a high-fat diet. Mice were divided into three groups (n=6) of normal diet, high-fat diet (=control), and high-fat diet with Cortex Phellodendri. After 12 weeks, we measured the three mice groups’ body weight, FBG, FBI, HOMA-IR, OGTT, the weight of epididymal fat and liver, the percentage of ATM, and the gene expression of TNF-α, IL-10, and CD68.
Results: Cortex Phellodendri significantly reduced blood glucose and oral glucose tolerance levels. It also reduced ATM numbers and TNF-α and CD68 gene expression and increased IL-10 gene expression.
Conclusions: This study suggests that Cortex Phellodendri normalized the blood glucose and reduced the expression of inflammatory markers. However, with respect to other indicators of metabolic function in obesity, there were no significant results.
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KEYWORD
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Cortex Phellodendri, obesity, blood glucose, anti-inflammatory, metabolic fuction
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